The MSC Musica is the first Musica-class cruise ship built in 2006 and operated by MSC Cruises. The vessel has 1,268 passenger cabins which can accommodate 2,550 passengers double occupancy, served by approximately 990 crew members.

65% of her passenger cabins have a balcony with a further 14% having a window. Inside cabins constitute 21% of the total. The majority of cabins have one or two extra pull-down bunks so her actual maximum passenger capacity is considerably higher than 2,536. These are employed to fulfill MSC's 'children go free' policy and, depending upon the itinerary and time of year, the ship can be busy with children. There are only 18 suites, all located forward on deck 15.

MSC Musica's itineraries cover Mediterranean ports including Dubrovnik; Corfu; Katakolon; Mykonos; Piraeus; Rhodes; Santorini; Bari; Venice; Valletta; Málaga; Palma de Mallorca and İzmir and Atlantic Ocean ports including Búzios; Ilha Grande; Rio de Janeiro; Salvador; Santos; Santa Cruz de Tenerife and Funchal. She currently crosses from the Mediterranean to South America late Autumn and returns in the Spring. She will be based in Durban from October 2018 for the Southern Africa summer. She will serve destinations in Mauritius, Mozambique, Réunion and other domestic destinations in South Africa